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- $Unique_ID{BRK00993}
- $Pretitle{}
- $Title{Questions About Marrow Transplant and Donation}
- $Subject{bone marrow transplant donor Blood Forming Organs primary stem cells
- cell cellular immune identical twin syngeneic transplants allogenic autologous
- aspirated intravenous infusion immunity system marrows donors}
- $Volume{D-7}
- $Log{}
-
- Copyright (c) 1991-92,1993 Tribune Media Services, Inc.
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- Questions About Marrow Transplant and Donation
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- QUESTION: We have received mail from a cousin who will soon be undergoing a
- marrow transplant. As a member of the family is it possible that our marrow
- would be useful? How is the marrow obtained and what is the process used for
- transplantation? Is this safe for both the donor and the patient? Please
- help us with the information we need to be of help.
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- ANSWER: Although you did not mention your exact relationship with the
- patient, nor his disease, I think it is pretty safe to state that you would
- not be any more likely to be a potential donor than someone not related to
- him. The marrow, which contains all of the primary or stem cells that divide
- and produce all the cellular elements of the blood and the immune cells as
- well, must be carefully matched to the patients immunologic type. An
- identical twin would be best (syngeneic transplant) but a brother or sister
- might serve, or any individual who is tissue type compatible (allogenic). In
- some cases, marrow can be removed from the patient (autologous) before
- treatment by irradiation or high intensity chemotherapy, and replanted after
- the therapy is completed. The marrow is obtained from the donor under strict
- sterile conditions, after the donor has been placed under a general
- anesthesia. The marrow is sucked (aspirated) from the marrow of the pelvic
- bones, and placed in a tissue culture media, treated to prevent coagulation.
- It is then given to the patient through an intravenous infusion directly
- following collection. There are few risks for the donor, primarily those
- associated with the anesthesia. Patients who are to receive this transplant
- must be treated in advance to reduce their own immunity system, which could
- reject the transplant and render the whole procedure useless. It takes time
- for the transplant to grow and produce enough cells to take over all the
- needed functions. Patients may have to remain hospitalized for as much as 3
- to 12 months after transplantation, guarded closely against infections which
- would have dire consequences as they can spread uncontrolled through the
- system that lacks of a functioning immune system. The technique, known and
- used for some thirty years, is not without difficulties, and expensive; but it
- may provide the only hope in some otherwise fatal diseases.
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- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
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